8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
CAS: 76939-46-3
Molecular Formula: C10H12BrN5NaO6P
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT - Names and Identifiers
| Name | 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT |
| Synonyms | 8-Bromo-cAMP CAMP, 8-BR, NA 8-BROMO-CAMP, NA 8-BROMO-CAMP, SODIUM SALT 8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE SODIUM SALT 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT 8-bromoadenosine-3',5'-cyclicmonophosphate(8-br-camp),sodiumsalt |
| CAS | 76939-46-3 |
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT - Physico-chemical Properties
| Molecular Formula | C10H12BrN5NaO6P |
| Molar Mass | 432.1 |
| Melting Point | >264°C )dec._ |
| Solubility | H2O: 100 mg/mL |
| Appearance | powder |
| Color | off-white |
| BRN | 7739743 |
| Storage Condition | -20°C |
| Stability | Hygroscopic, Moisture Sensitive |
| Physical and Chemical Properties | Bioactive 8-bromo-cAMP (8-Br-Camp) is a cell-permeable cyclic AMP(cAMP) analog that activates a cAMP-dependent protein kinase with a Ka value of 0.05 μM. It is a PKA activator. |
| In vitro study | 8-bromo-Camp increases the reprogramming efficiency of human newborn foreskin fibrinogen (HFF1) cells. In bronchial epithelial cells, 8-bromo-camp reduces HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE;ADAM-17) activity and subsequent TNF-α release. |
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29349990 |
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT - Uses and synthesis methods
Target
Target Value
PKA
0.05 μM(Ka)
in vitro studies
8-Bromo-cAMP improves the reprogramming efficiency of human newborn foreskin fibrogen (HFF1) cells. In bronchial epithelial cells, 8-Bromo-cAMP reduced HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE;ADAM-17) activity and subsequent TNF-α release.
Last Update：2024-04-10 22:41:03
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